Table of Contents
Journal of Allergy
Volume 2013, Article ID 654104, 6 pages
http://dx.doi.org/10.1155/2013/654104
Research Article

Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control

1Department of Pediatrics, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar
2Weill Cornell Medical College, Doha, Qatar
3Laboratory Medicine and Pathology, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar
4Medical Research Center, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar

Received 4 August 2013; Revised 12 November 2013; Accepted 25 November 2013

Academic Editor: Harald Renz

Copyright © 2013 Atqah Abdul Wahab et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There is growing evidence of a positive correlation between asthma and obesity in children and adults. Leptin and adiponectin regulate several metabolic and inflammatory functions. This study aims to evaluate serum leptin and adiponectin concentrations in asthmatic school children to investigate their association with obesity and the degree of asthma control. Obese asthmatic (OA) and nonobese asthmatic (NOA) children, aged 7 to 14, were randomly enrolled in this prospective study. Data on demographic, anthropometric, serum lipids, and spirometric measures and allergy status were collected and analyzed. Serum leptin was significantly higher ( versus ; ) and adiponectin levels were lower ( versus ; ) in OA compared to NOA children. The uncontrolled group had higher leptin and lower adiponectin levels compared to well and partially controlled asthma. BMI was positively correlated with leptin ( ; ) and negatively with adiponectin ( ; ). Mean BMI and leptin levels were observed to be higher in girls compared to boys. Stepwise multiple linear regression analysis showed that higher BMI and female gender had significant effect on serum leptin levels. Among asthmatic children higher serum leptin and lower adiponectin levels were significantly associated with obesity and showed no significant association with degree of asthma controls.