The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways
Effect of CNP and ectoine on OVA provocation-induced lung inflammation in sensitized animals (control groups and exposure groups ). (a) Experimental design. Animals were sensitized by repetitive intraperitoneal OVA application. At day 0, 5 mg/kg CNP in the presence or absence of 1 mM ectoine was applied to the animals. OVA provocation by inhalation (1%, 30 min) was performed 12 h after treatment. Measurements were made 24 h after challenge. (b) Total number of cells per mL BAL; (c) total number of neutrophilic granulocytes per mL BAL; (d) total number of macrophages and monocytes per mL BAL; (e) total number of other cells including lymphocytes and eosinophilic granulocytes.
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