Table of Contents
Journal of Allergy
Volume 2015 (2015), Article ID 312052, 7 pages
http://dx.doi.org/10.1155/2015/312052
Review Article

Omega-3 Fatty Acids Supplementation in Children to Prevent Asthma: Is It Worthy?—A Systematic Review and Meta-Analysis

1Department of Paediatrics, S.B.K.S MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India
2Department of Periodontics, K.M.S DCH, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India
3Department of Medicine, S.B.K.S MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India

Received 23 May 2015; Revised 4 August 2015; Accepted 6 August 2015

Academic Editor: Stephen P. Peters

Copyright © 2015 Prasad Muley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. S. Braman, “The global burden of asthma,” Chest, vol. 130, no. 1, supplement, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. M. C. Bell and W. W. Busse, “Severe asthma: an expanding and mounting clinical challenge,” Journal of Allergy and Clinical Immunology: In Practice, vol. 1, no. 2, pp. 110–121, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Saravanan, N. C. Davidson, E. B. Schmidt, and P. C. Calder, “Cardiovascular effects of marine omega-3 fatty acids,” The Lancet, vol. 376, no. 9740, pp. 540–550, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Muley, P. Muley, and M. Shah, “ALA, fatty fish or marine n-3 fatty acids for preventing DM?: a systematic review and meta-analysis,” Current Diabetes Reviews, vol. 10, no. 3, pp. 158–165, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. P. C. Calder, “Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?” British Journal of Clinical Pharmacology, vol. 75, no. 3, pp. 645–662, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. C. M. Yates, P. C. Calder, and G. Ed Rainger, “Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease,” Pharmacology & Therapeutics, vol. 141, no. 3, pp. 272–282, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Miyata and M. Arita, “Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases,” Allergology International, vol. 64, no. 1, pp. 27–34, 2015. View at Publisher · View at Google Scholar
  8. M. Calvani, C. Alessandri, S. M. Sopo et al., “Consumption of fish, butter and margarine during pregnancy and development of allergic sensitizations in the offspring: role of maternal atopy,” Pediatric Allergy and Immunology, vol. 17, no. 2, pp. 94–102, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Romieu, M. Torrent, R. Garcia-Esteban et al., “Maternal fish intake during pregnancy and atopy and asthma in infancy,” Clinical and Experimental Allergy, vol. 37, no. 4, pp. 518–525, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. M. T. Salam, Y.-F. Li, B. Langholz, and F. D. Gilliland, “Maternal fish consumption during pregnancy and risk of early childhood asthma,” Journal of Asthma, vol. 42, no. 6, pp. 513–518, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Sausenthaler, S. Koletzko, B. Schaaf et al., “Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age,” The American Journal of Clinical Nutrition, vol. 85, no. 2, pp. 530–537, 2007. View at Google Scholar · View at Scopus
  12. S. M. Willers, G. Devereux, L. C. A. Craig et al., “Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children,” Thorax, vol. 62, no. 9, pp. 772–779, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Andreasyan, A.-L. Ponsonby, T. Dwyer et al., “A differing pattern of association between dietary fish and allergen-specific subgroups of atopy,” Allergy, vol. 60, no. 5, pp. 671–677, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Chatzi, M. Torrent, I. Romieu et al., “Diet, wheeze, and atopy in school children in Menorca, Spain,” Pediatric Allergy and Immunology, vol. 18, no. 6, pp. 480–485, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Dunder, L. Kuikka, J. Turtinen, L. Räsänen, and M. Uhari, “Diet, serum fatty acids, and atopic diseases in childhood,” Allergy: European Journal of Allergy and Clinical Immunology, vol. 56, no. 5, pp. 425–428, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Antova, S. Pattenden, B. Nikiforov et al., “Nutrition and respiratory health in children in six Central and Eastern European countries,” Thorax, vol. 58, no. 3, pp. 231–236, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Hodge, C. M. Salome, J. K. Peat, M. M. Haby, W. Xuan, and A. J. Woolcock, “Consumption of oily fish and childhood asthma risk,” Medical Journal of Australia, vol. 164, no. 3, pp. 137–140, 1996. View at Google Scholar · View at Scopus
  18. I. Kull, A. Bergström, G. Lilja, G. Pershagen, and M. Wickman, “Fish consumption during the first year of life and development of allergic diseases during childhood,” Allergy, vol. 61, no. 8, pp. 1009–1015, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Nafstad, W. Nystad, P. Magnus, and J. J. K. Jaakkola, “Asthma and allergic rhinitis at 4 years of age in relation to fish consumption in infancy,” Journal of Asthma, vol. 40, no. 4, pp. 343–348, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Yang, P. Xun, and K. He, “Fish and fish oil intake in relation to risk of asthma: a systematic review and meta-analysis,” PLoS ONE, vol. 8, no. 11, Article ID e80048, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Hodge, C. M. Salome, J. M. Hughes et al., “Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children,” European Respiratory Journal, vol. 11, no. 2, pp. 361–365, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Nagakura, S. Matsuda, K. Shichijyo, H. Sugimoto, and K. Hata, “Dietary supplementation with fish oil rich in ω-3 polyunsaturated fatty acids in children with bronchial asthma,” European Respiratory Journal, vol. 16, no. 5, pp. 861–865, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Mihrshahi, J. K. Peat, K. Webb, W. Oddy, G. B. Marks, and C. M. Mellis, “Effect of omega-3 fatty acid concentrations in plasma on symptoms of asthma at 18 months of age,” Pediatric Allergy and Immunology, vol. 15, no. 6, pp. 517–522, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Chan-Yeung, A. Ferguson, W. Watson et al., “The Canadian childhood asthma primary prevention study: outcomes at 7 years of age,” Journal of Allergy and Clinical Immunology, vol. 116, no. 1, pp. 49–55, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Almqvist, F. Garden, W. Xuan et al., “Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years,” Journal of Allergy and Clinical Immunology, vol. 119, no. 6, pp. 1438–1444, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Al Biltagi, A. Abdul Baset, M. Bassiouny, M. Al Kasrawi, and M. Attia, “Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study,” Acta Paediatrica, vol. 98, no. 4, pp. 737–742, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. B. J. Manley, M. Makrides, C. T. Collins et al., “High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes,” Pediatrics, vol. 128, no. 1, pp. e71–e77, 2011. View at Publisher · View at Google Scholar
  28. J. E. Lang, E. B. Mougey, H. Allayee et al., “Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods,” Contemporary Clinical Trials, vol. 34, no. 2, pp. 326–335, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Mihrshahi, J. K. Peat, G. B. Marks et al., “Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS),” Journal of Allergy and Clinical Immunology, vol. 111, no. 1, pp. 162–168, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. G. B. Marks, S. Mihrshahi, A. S. Kemp et al., “Prevention of asthma during the first 5 years of life: a randomized controlled trial,” Journal of Allergy and Clinical Immunology, vol. 118, no. 1, pp. 53–61, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. E. E. Birch, J. C. Khoury, C. L. Berseth et al., “The Impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children,” Journal of Pediatrics, vol. 156, no. 6, pp. 902–906, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. N. D'Vaz, S. J. Meldrum, J. A. Dunstan et al., “Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial,” Pediatrics, vol. 130, no. 4, pp. 674–682, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. K. K. W. Ng, D. Crisafulli, E. G. Belousova et al., “Eight-year outcomes of the Childhood Asthma Prevention Study,” Journal of Allergy and Clinical Immunology, vol. 126, no. 2, pp. 388–389.e3, 2010. View at Publisher · View at Google Scholar
  34. A. E. Barden, T. A. Mori, J. A. Dunstan et al., “Fish oil supplementation in pregnancy lowers F2-isoprostanes in neonates at high risk of atopy,” Free Radical Research, vol. 38, no. 3, pp. 233–239, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. J. A. Dunstan, L. R. Mitoulas, G. Dixon et al., “The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial,” Pediatric Research, vol. 62, no. 6, pp. 689–694, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. J. A. Dunstan, T. A. Mori, A. Barden et al., “Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition,” European Journal of Clinical Nutrition, vol. 58, no. 3, pp. 429–437, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Krauss-Etschmann, R. Shadid, C. Campoy et al., “Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial,” American Journal of Clinical Nutrition, vol. 85, no. 5, pp. 1392–1400, 2007. View at Google Scholar · View at Scopus
  38. K. Warstedt, C. Furuhjelm, K. Duchen, K. Fälth-Magnusson, and M. Facerás, “The effects of omega-3 fatty acid supplementation in pregnancy on maternal eicosanoid, cytokine, and chemokine secretion,” Pediatric Research, vol. 66, no. 2, pp. 212–217, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Nagakura, S. Matsuda, K. Shichijyo, H. Sugimoto, and K. Hata, “Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma,” European Respiratory Journal, vol. 16, no. 5, pp. 861–865, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Barros, A. Moreira, J. Fonseca et al., “Dietary intake of alpha-linolenic acid and low ratio of n-6:n-3 PUFA are associated with decreased exhaled NO and improved asthma control,” British Journal of Nutrition, vol. 106, no. 3, pp. 441–450, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. R. Kitz, M. A. Rose, R. Schubert et al., “Omega-3 polyunsaturated fatty acids and bronchial inflammation in grass pollen allergy after allergen challenge,” Respiratory Medicine, vol. 104, no. 12, pp. 1793–1798, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. I. Kompauer, H. Demmelmair, B. Koletzko, G. Bolte, J. Linseisen, and J. Heinrich, “Association of fatty acids in serum phospholipids with lung function and bronchial hyperresponsiveness in adults,” European Journal of Epidemiology, vol. 23, no. 3, pp. 175–190, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. J. Li, P. Xun, D. Zamora et al., “Intakes of long-chain omega-3 (n-3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study,” American Journal of Clinical Nutrition, vol. 97, no. 1, pp. 173–178, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. T. M. McKeever, S. A. Lewis, P. A. Cassano et al., “The relation between dietary intake of individual fatty acids, FEV1 and respiratory disease in Dutch adults,” Thorax, vol. 63, no. 3, pp. 208–214, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. R. K. Woods, J. M. Raven, E. H. Walters, M. J. Abramson, and F. C. K. Thien, “Fatty acid levels and risk of asthma in young adults,” Thorax, vol. 59, no. 2, pp. 105–110, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. J. S. Burns, D. W. Dockery, L. M. Neas et al., “Low dietary nutrient intakes and respiratory health in adolescents,” Chest, vol. 132, no. 1, pp. 238–245, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. R. K. Woods, F. C. Thien, and M. J. Abramson, “Dietary marine fatty acids (fish oil) for asthma in adults and children,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD001283, 2002. View at Google Scholar · View at Scopus
  48. C. Anandan, U. Nurmatov, and A. Sheikh, “Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis,” Allergy, vol. 64, no. 6, pp. 840–848, 2009. View at Publisher · View at Google Scholar · View at Scopus