Journal of Allergy / 2015 / Article / Tab 1

Review Article

Omega-3 Fatty Acids Supplementation in Children to Prevent Asthma: Is It Worthy?—A Systematic Review and Meta-Analysis

Table 1

Details of excluded studies.

Serial numberAuthorTitle of paperReason for exclusion

1 Hodge et al., 1996 [17]Consumption of oily fish and childhood asthma riskCase control study

2Hodge et al., 1998 [21]Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in childrenAsthma severity scoring was based on symptoms while, in other study which reported asthma scoring system, it was based on auscultatory findings, hence excluded from meta-analysis

3Nagakura et al., 2000 [22]Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma (asthma severity score)Asthma severity scoring was based on auscultatory findings while, in other study which reported asthma scoring system, it was based on symptoms, hence excluded from meta-analysis

4Mihrshahi et al., 2004 [23]Effect of omega-3 fatty acid concentrations in plasma on symptoms of asthma at 18 months of ageAssessed association of plasma level of omega-3 FA after giving tuna fish and margarine oil with incidence of asthma

5Chan-Yeung et al., 2005 [24]Canadian childhood asthma primary prevention study: outcomes at 7 years of ageDid not use omega-3 FA as intervention

6Almqvist et al., 2007 [25]Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 yearsObservational study

7Al Biltagi et al., 2009 [26]Omega-3 fatty acids, vitamin C, and Zn supplementation in asthmatic children: a randomized self-controlled studySimultaneously used omega-3 FA, vit. C, and Zn supplementation

8Manley et al., 2011 [27]High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomesSupplementation given to mothers and EBM (expressed breast milk) fed to the babies

9Lang et al., 2013 [28]Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methodsResults not stated