Journal of Allergy / 2015 / Article / Tab 2 / Review Article
Omega-3 Fatty Acids Supplementation in Children to Prevent Asthma: Is It Worthy?—A Systematic Review and Meta-Analysis Table 2 Details of included studies.
Serial number Author Year Place Sample size Age/sex Intervention and dose Comparator and dose Follow-up (years) Outcomes studied Conflict of interests Funding 1 Mihrshahi et al. [29 ] 2003 Australia 616/554 6–18 months/ both o-3–rich tuna fish oil (500 mg) from the age of 6 months. Sunola oil 1 Number of episodes of wheeze or cough lasting for >1 week not associated with colds None Institute of Health 2 Marks et al. [30 ] 2006 Australia 616/516 6 months to 5 years Oil capsules with 500 mg tuna fish oil (37% o-3 PUFA + 6% o-6) Oil capsules with 0.3% o-3 + 7% o-6 PUFA 5 Episodes of wheeze, asthma None Institute of Health 3 Birch et al. [31 ] 2010 USA 147/89 <5 days–12 months/ both DHA and ARA as 0.32%–0.36% and 0.64%–0.72% of total FA Enfamil with iron 3 Diagnoses of wheezing, asthma None National Institute of Health USA 4 D’Vaz et al. [32 ] 2012 Australia 420/323 0–6 months/ both 650 mg fish oil capsules (280 mg DHA + 110 mg EPA) daily 650 mg olive oil (66.6% n-9 oleic acid) 0.5 Physician diagnosed IgE-mediated asthma episodes None National Health and Medical Research Council (NHMRC) 5 Ng et al. [33 ] 2010 Australia 616/450 Birth to 5 years/ both Oil capsules, 500 mg tuna fish oil (37% o-3 PUFA + 6% o-6 PUFA) 500 mg Sunola oil capsules (0.3% o-3 + 7% o-6 PUFA) 8 ARR of wheezing episodes, asthma None Institute of Health
DHA: docosahexaenoic acid; EPA: eicosapentaenoic acid; ARA: arachidonic acid; PUFA: polyunsaturated fatty acid; ARR: absolute risk reduction; o-3: omega-3; o-6: omega-6; FA: fatty acids; sample size: number of participants who were given supplements/number of participants who completed the trial.