Journal of Allergy / 2015 / Article / Tab 1

Review Article

Twin Studies of Atopic Dermatitis: Interpretations and Applications in the Filaggrin Era

Table 1

Population-based twin studies of the concordance and heritability of atopic dermatitis.

Study CountryAge
(years)

(pairs)
MZ rateDZ rateMZ/DZ
ratio
Heritability
(%)
Diagnostic
method

Edfors-Lubs (1971) [7]Sweden42–8169960.1540.0453.42Self-report
Schultz Larsen et al. (1986) [8]Denmark7–215920.860.214.1Clinical examination
Larsen (1993) [9]Denmark8–228120.720.233.13Clinical examination
Lichtenstein and Svartengren (1997) [10]Sweden7–91339Parent-report
 Boys0.540.351.5474
 Girls0.730.401.8371
Strachan et al. (2001) [11]UK18–72873Clinical examination
 <500.510.341.50
 >500.470.095.22
Nystad et al. (2005) [12]Norway18–35333469Self-report
 Boys0.430.067.17
 Girls0.440.104.40
Thomsen et al. (2007) [13]Denmark12–41115150.570.212.71Self-report
 Boys82
 Girls80
Jäderberg et al. (2012) [14]Denmark3–209694Self-report/parent-report
 Assisted reproduction86
 Spontaneous conception78

MZ, monozygotic; DZ, dizygotic.