Review Article

The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases

Table 1

Polyglutamine binding peptides isolated from phage display screening.

NameQ62/Q19
binding ratio
Sequence (X5-fixed-X5)

QBP11.66Ser-Asn-Trp-Lys-Trp-Trp-Pro-Gly-Ile-Phe-Asp
QBP21.31His-Trp-Trp-Arg-Ser-Trp-Tyr-Ser-Asp-Ser-Val
QBP31.30His-Glu-Trp-His-Trp-Trp-His-Gln-Glu-Ala-Ala
QBP41.27Trp-Gly-Leu-Glu-His-Phe-Ala-Gly-Asn-Lys-Arg
QBP51.25Trp-Trp-Arg-Trp-Asn-Trp-Ala-Thr-Pro-Val-Asp
QBP61.23Trp-His-Asn-Tyr-Phe-His-Trp-Trp-Gln-Asp-Thr
SCRTrp-Pro-Ile-Trp-Ser-Lys-Gly-Asn-Asp-Trp-Phe