Catalytic Site Cysteines of Thiol Enzyme: Sulfurtransferases

Table 1

Typical thiol enzymes.

		Enzyme	Oxidative inactivation
Classification		name defined as a thiol enzyme
Oxidoreductase		Glutathione family [4]	Not defined
		Glutaredoxin family [5]	Not defined
		Glyceraldehyde-3-phosphate dehydrogenase [6]	Yes [7, 8]
		Peptide-methionine (S)-S-oxide reductase [9]	Not defined
		Peroxiredoxin [10, 11]	Yes [12]
		Sulphiredoxin [13]	Not defined
		Thioredoxin family [14]	Not defined
Transferase	Desulfurase	Cysteine desulfurase^1 [15]	Not defined
	Phosphatase	Cdc^2 25 family [16]	Yes [17, 18]
		Protein-tyrosine phosphatases [19]	Yes [20]
	Sulfurtransferase	Mercaptopyruvate sulfurtransferase [21, 22]	Yes [23]
		Thiosulfate sulfurtransferase [24]	Yes [25, 26]
Hydrolase	Cysteine protease	Actinidain family [27]	Not defined
		Bromelain family [28]	Yes [29]
		Calpain family [30]	Yes [31]
		Caspase family [32]	Yes [33]
		Cathepsin family [34]	Yes [35]
		Chymopapain family [36]	Yes [37]
		Ficin family [38]	Not defined
		Mir1-CP^3 [39]	Not defined
		Papain family [40]	Yes [41]
Isomerase		Protein disulfide isomerase [42]	Not defined

¹pyridoxal 5′-phosphate-dependent enzyme
²cdc, cell division cycle
³Mir1-CP. Maize insect resistance-cysteine protease