Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin
Figure 3
(a) Time course of the religation experiment between the R11 substrate and the covalent complex of the wild-type or Asp677Gly-Val703Ile mutant. (b) Percentage of the remaining covalent complex, plotted at different times for the wild-type enzyme (black line) and the Asp677Gly-Val703Ile mutant (red line).
