HDAC6 and futsch levels are controlled by TBPH in Drosophila. Two genes are currently described as direct targets of TBPH in Drosophila melanogaster. Both HDAC6 and futsch mRNAs are bound by TBPH. In particular, TBPH silencing decreases HDAC6 mRNA and, as a consequence, protein levels. On the other hand, TBPH silencing causes a drop only in futsch protein levels but not in mRNA expression, suggesting in this case an involvement of TDP-43 in either the mRNA transport or translations systems.
