Cancer Treatment Using Peptides: Current Therapies and Future Prospects

Table 1

LHRH agonists and new generation antagonists available in the market.

Peptide	Sequence comparison	Indications
Agonists
Buserelin	Pyr-His-Trp-Ser-Tyr-D-Ser(OtBu)-Leu-Arg-Pro-NHEt	Prostate cancer
Gonadorelin	Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2	Cystic ovarian disease, agent for evaluating hypothalamic-pituitary gonadotropic function
Goserelin	Pyr-His-Trp-Ser-Tyr-D-Ser(OtBu)-Leu-Arg-Pro-AzGly-NH2	Prostate cancer; breast cancer
Histrelin	Pyr-His-Trp-Ser-Tyr-D-His(N-benzyl)-Leu-Arg-Pro-NHEt	Prostate cancer; breast cancer
Leuprolide	Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt	Prostate cancer; breast cancer
Nafarelin	Pyr-His-Trp-Ser-Tyr-2Nal-Leu-Arg-Pro-Gly-NH2	Treat symptoms of endometriosis, central precocious puberty
Triptorelin	Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2	Prostate cancer; breast cancer
Antagonists
Abarelix	Ac-D-2Nal-D-4-chloroPhe-D-3-(3′-pyridyl) Ala-Ser-(N-Me)Tyr-D-Asn-Leu-isopropylLys-Pro-DAla-NH2	Prostate cancer
Cetrorelix	Ac-D-2Nal-D-4-chloroPhe-D-3-(3′-pyridyl) Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2	Prostate cancer; breast cancer
Degarelix	Ac-D-2Nal-D-4-chloroPhe-D-3-(3′-pyridyl) Ala-Ser-4-aminoPhe(L-hydroorotyl)-D-4-aminoPhe(carbamoyl)-Leu-isopropylLys-Pro-D-Ala-NH2	Prostate cancer
Ganirelix	Ac-D-2Nal-D-4-chloroPhe-D-3-(3′-pyridyl) Ala-Ser-Tyr-D-(N9, N10-diethyl)-homoArg-Leu-(N9, N10-diethyl)-homoArg-Pro-D-Ala-NH2	Fertility treatment