Journal of Amino Acids / 2013 / Article / Tab 1

Research Article

An Amino Acids Mixture Improves the Hepatotoxicity Induced by Acetaminophen in Mice

Table 1

Body weight, liver weight, and survival rates in mice 8 h after administration of acetaminophen (APAP, 2 mmol/kg ip) alone or in presence of N-acetylcysteine (NAC) and a mixture of L-cysteine, L-methionine, and L-serine in a ratio 2 : 1 : 1 (DDM-GSH).

TreatmentBody weight (g)Liver weight (g/10 g b.w.)Survival rates (%)

Saline23 ± 40.25 ± 0.01100
APAP24 ± 30.32 ± 0.01*70*
NAC 0.9 mmol/kg + APAP24 ± 30.30 ± 0.01*90*
NAC 1.8 mmol/kg + APAP23 ± 50.26 ± 0.03#100#
NAC 3.6 mmol/kg + APAP23 ± 40.26 ± 0.02##100#
DDM-GSH 0.4 mmol/kg + APAP25 ± 30.27 ± 0.02#100#
DDM-GSH 0.8 mmol/kg + APAP23 ± 20.24 ± 0.01##100#
DDM-GSH 1.6 mmol/kg + APAP26 ± 40.22 ± 0.02###100#

Saline (10 mL/kg), NAC, and DDM-GSH were given ip 1 h before APAP. Values are reported as mean ± SE ( = 10 animals/group). * < 0.05 versus saline; # < 0.05, ## < 0.01, and ### < 0.001 versus APAP.

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