Tissue Taurine Depletion Alters Metabolic Response to Exercise and Reduces Running Capacity in Mice

Figure 3

Expression of AMPK subunits and genes of PPARα and its targets in tibial anterior muscle of WT and TauTKO mice. (a) Gene expression of AMPK β2 was measured by qRT-PCR method. . versus WT. (b) AMPK subunits (α1, α2, β1, and β2) and GAPDH in TA muscle of WT and TauTKO mice were detected by Western blot. . versus WT. (c) Phospho-ACC (Ser79) and GAPDH in skeletal muscle before and 20 min after treadmill running were detected. Data are mean ± se. . , versus rest group. (d) The change in genes of PPARα (ppara), carnitine palmitoyl transferase 2 (cpt2), short-chain enoyl CoA hydratase (echs1), and glutathione peroxidase c (gpx3) was analyzed by quantitative RT-PCR. Data are mean ± SE. . versus WT.

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