Table of Contents
Journal of Amino Acids
Volume 2015, Article ID 254583, 7 pages
http://dx.doi.org/10.1155/2015/254583
Research Article

Properties of Taurine Release in Glucose-Free Media in Hippocampal Slices from Developing and Adult Mice

Medical School, 33014 University of Tampere, Finland

Received 14 May 2015; Accepted 21 July 2015

Academic Editor: Hari Shanker Sharma

Copyright © 2015 Simo S. Oja and Pirjo Saransaari. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The release of preloaded [3H]taurine from hippocampal slices from developing 7-day-old and young adult 3-month-old mice was studied in a superfusion system in the absence of glucose. These hypoglycemic conditions enhanced the release at both ages, the effect being markedly greater in developing mice. A depolarizing K+ concentration accentuated the release, which indicates that it was partially mediated by exocytosis. The anion channel blockers were inhibitory, witnessing the contribution of ion channels. NO-generating agents fomented the release as a sign of the participation of excitatory amino acid receptors. The other second messenger systems were apparently less efficient. The much greater taurine release could be a reason for the well-known greater tolerance of developing nervous tissue to lack of glucose.