Properties of Taurine Release in Glucose-Free Media in Hippocampal Slices from Developing and Adult Mice

Table 2

Effects of nitric oxide generators on taurine release from hippocampal slices from 3-month-old and 7-day-old mice in hypoglycemia.

Effectors	Efflux rate constants (×10^−3 min^−1) ± SEM
	3-month-old				7-day-old
	Basal (control)	2.36 ± 0.11	(20)	1.93 ± 0.18	(11)	1.34 ± 0.08	(31)	1.20 ± 0.11	(11)
+50 mM K^+ (control)			2.92 ± 0.21	(10)			1.90 ± 0.10	(12)
SNAP 1.0 mM	4.31 ± 0.22	(7)	5.44 ± 0.14	(4)	2.84 ± 0.11	(8)	2.17 ± 0.07	(4)
+50 mM K^+			5.35 ± 0.15	(4)			2.34 ± 0.08	(4)
SNP 1.0 mM	3.17 ± 0.13	(15)	4.23 ± 0.38	(8)	1.80 ± 0.21	(7)	1.65 ± 0.13	(4)
+50 mM K^+			4.41 ± 0.77	(4)			1.98 ± 0.10	(4)
Hydroxylamine 5.0 mM	5.16 ± 0.17	(7)	6.04 ± 0.76	(7)	3.82 ± 0.33	(8)	3.44 ± 0.16	(4)
+50 mM K^+			7.03 ± 0.28	(4)			3.84 ± 0.10	(4)

The effectors were added at the beginning of superfusion and 50 mM K⁺ at 30 min. The results show the efflux rate constants ± SEM (×10⁻³ min⁻¹) for the time intervals of 20–30 min () and 34–50 min without the excess of K⁺ or in the presence of 50 mM K⁺ () with the number of independent experiments in parenthesis. SNAP: S-nitroso-N-acetylpenicillamine; SNP: sodium nitroprusside. Significance of differences from the corresponding controls: , .