Table of Contents
Journal of Amino Acids
Volume 2016 (2016), Article ID 8576730, 9 pages
Research Article

Postprandial Levels of Branch Chained and Aromatic Amino Acids Associate with Fasting Glycaemia

1Department of Clinical Sciences, Lund University, Jan Waldenströms Gata 35, 21421 Malmö, Sweden
2Department of Cardiology, Skåne University Hospital, Entrance 35, 20502 Malmö, Sweden
3Department of Internal Medicine, Skåne University Hospital, Ruth Lundskogs Gata 3, 20502 Malmö, Sweden

Received 2 February 2016; Revised 4 April 2016; Accepted 14 April 2016

Academic Editor: Hieronim Jakubowski

Copyright © 2016 Filip Ottosson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


High fasting plasma concentrations of isoleucine, phenylalanine, and tyrosine have been associated with increased risk of hyperglycaemia and incidence of type 2 diabetes. Whether these associations are diet or metabolism driven is unknown. We examined how the dietary protein source affects the postprandial circulating profile of these three diabetes associated amino acids (DMAAs) and tested whether the postprandial DMAA profiles are associated with fasting glycaemia. We used a crossover design with twenty-one healthy individuals and four different isocaloric test meals, containing proteins from different dietary sources (dairy, fish, meat, and plants). Analysis of the postprandial DMAAs concentrations was performed using targeted mass spectrometry. A DMAA score was defined as the sum of all the three amino acid concentrations. The postprandial area under the curve (AUC) of all the three amino acids and the DMAA score was significantly greater after intake of the meal with dairy protein compared to intake of the three other meals. The postprandial AUC for the DMAA score and all the three amino acids strongly associated with fasting glucose level and insulin resistance. This indicates the importance of the postprandial kinetics and metabolism of DMAAs in understanding the overall association between DMAAs and glycaemia.