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Journal of Applied Chemistry
Volume 2013 (2013), Article ID 316137, 5 pages
http://dx.doi.org/10.1155/2013/316137
Research Article

Quantification of Benazepril Hydrochloride and Hydrochlorothiazide in Tablet Dosage Form by Simultaneous Equation Spectrophotometric Method

Department of Pharmaceutical Chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, Beyond GIDC Phase IV, P.O. Bar 53, Vithal Udyog nagar, New Vallabh Vidyanagar, Anand, Gujarat 388 121, India

Received 26 March 2013; Revised 5 August 2013; Accepted 9 August 2013

Academic Editor: Guang-Fu Yang

Copyright © 2013 Varsha Parmar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Simple, accurate, precise, reproducible, requiring no prior separation, and economical procedures for simultaneous estimation of benazepril hydrochloride (BEN) and Hydrochlorothiazide (HCT) in tablet dosage form have been developed. Simultaneous equation method employs for estimation of both drugs in methanol at 240 nm and 270 nm as two analytical wavelengths. BEN and HCT at their respective (240 nm and 270 nm) show linearity in a concentration range of 2–12 μg/mL and 4–14 μg/mL. Recovery studies for BEN are 100.0–100.6% and 99.8–100.0% for HCT in the case of simultaneous equation method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific.