Journal of Applied Chemistry / 2013 / Article / Tab 2

Research Article

Synthesis, Antimicrobial, and Anti-HIV1 Activity of Quinazoline-4(3H)-one Derivatives

Table 2

Anti-HIV1 Activity of compounds.

EntryStrainIC50 (µg/mL)aCC50 (µg/mL)b

7IIIB>48.948.9
8IIIB>37.537.5
9IIIB>0.4560.456
10IIIB>0.4820.482
11IIIB>35.135.1
AZTIIIB0.001265.9

Effective concentration of compounds, achieving 50% protection of MT-4 cells against cytopathic effect of HIV.
bCytotoxic concentration of compounds, required to reduce the viability of mock infected MT-4 cells by 50%.

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