Synthesis, Antimicrobial, and Anti-HIV1 Activity of Quinazoline-4(3H)-one Derivatives

Table 2

Anti-HIV1 Activity of compounds.

Entry	Strain	IC50 (µg/mL)^a	CC50 (µg/mL)^b
7	IIIB	>48.9	48.9
8	IIIB	>37.5	37.5
9	IIIB	>0.456	0.456
10	IIIB	>0.482	0.482
11	IIIB	>35.1	35.1
AZT	IIIB	0.0012	65.9

aEffective concentration of compounds, achieving 50% protection of MT-4 cells against cytopathic effect of HIV.
^bCytotoxic concentration of compounds, required to reduce the viability of mock infected MT-4 cells by 50%.