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Journal of Applied Chemistry
Volume 2014 (2014), Article ID 152734, 5 pages
Research Article

Chalcogenide Thin Film Substrate for Protein Biochip Application

1Department of Chemistry, Saint Petersburg State University, Universitetskii Prospekt 26, Petrodvorets, Saint Petersburg 198504, Russia
2JSC HoloGrate, Prospekt Rimskogo-Korsakova 45, Saint Petersburg 190068, Russia

Received 30 October 2013; Accepted 17 January 2014; Published 5 March 2014

Academic Editor: Ioana Demetrescu

Copyright © 2014 A. S. Tveryanovich et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diagnostic of pathogen in the human biological liquids by biochip technology is an intensively developed methodic now. The main and the most important part of biochip is the adsorbing layer. Adsorption properties of chalcogenide films to protein (rat monoclonal antibodies) were tested. The films were prepared by conventional thermal deposition technique and by pulsed laser deposition technique. Two methods were used for forming in the films the two-dimensional map of adsorbing places for probe testing. One is using photoresist properties of chalcogenide films; another is using photo-induced oxidation of chalcogenide films. It was shown Good selectivity of the developed structures to protein markers was shown.