Table of Contents
Journal of Applied Chemistry
Volume 2014, Article ID 450294, 7 pages
Research Article

Measurement and Correlation for Solubility of Some Pyrimidine Derivatives in Different Solvents

Physical Chemistry Laboratory, Department of Chemistry, Saurashtra University, Rajkot, Gujarat 360005, India

Received 15 August 2013; Accepted 9 December 2013; Published 3 March 2014

Academic Editor: Zhen Zhao

Copyright © 2014 Kapil Bhesaniya and Shipra Baluja. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some new pyrimidine derivatives have been synthesized and their characterization was done by IR, NMR, and mass spectral data. The solubility of these synthesized compounds has been studied in methanol, N,N dimethylformamide (DMF), and carbon tetrachloride (CCl4) by gravimetrical method from 298.15 to 328.15 K under atmospheric pressure and the solubility data were correlated against temperature. The solubility is found to increase with temperature and order of solubility is DMF > methanol > CCl4. The experimental solubility data is correlated with the modified Apelblat equation. Some thermodynamic parameters such as dissolution enthalpy, Gibbs energy of dissolution, and entropy of mixing have also been calculated.