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Journal of Applied Chemistry
Volume 2014 (2014), Article ID 835758, 6 pages
Research Article

Benign Methodology and Efficient Catalysis for the One-Pot Multicomponent Synthesis of Dihydropyrimidinones and Thiones: A New Key for Old Lock

1Center for Health Studies, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia
2Institute of Science, Nagpur University, Nagpur 440001, India
3Laboratoire de Chimie des Matériaux, Université Mohammed Premier, 6000 Oujda, Morocco

Received 29 October 2013; Accepted 13 March 2014; Published 9 April 2014

Academic Editor: Guang-Fu Yang

Copyright © 2014 Parvez Ali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the present communication, under the influence of microwaves, cuprous chloride has been demonstrated to be safe, mild, efficient, and inexpensive catalyst for the Biginelli discovered multicomponent reaction (MCR) between aromatic aldehydes, urea/substituted urea, and ethyl acetoacetate to produce structurally diverse dihydropyrimidin-2(1H)-ones (DHPMs) and thiones in an ecofriendly solvent-free protocol. The practical and simple protocol led to excellent yields of the dihydropyrimidin-2(1H)-one derivatives under mild reaction conditions and within short span of reaction times with easy reaction workup by maintaining excellent atom economy.