Journal of Applied Chemistry / 2015 / Article / Tab 3

Research Article

Proficient Procedure for Preparation of Quinoline Derivatives Catalyzed by NbCl5 in Glycerol as Green Solvent

Table 3

Synthesis of quinolones by the NbCl5-catalyzed in glycerolea.

EntrySubstrate 1Substrate 2Quinoline 3Reaction time (min)Yield (%)b

11a
2a
3a
1595

21b
2a3b
2098

31a2b
3c
2593

41b2b3d
3595

51a2c
3e
5087

61b2c3f
6078

71a2d
3g
4582

81b2d3h
5085

91b2e
3i
7080

101a2f
3j
6078
111b2f3k
4584

121a2g
3l
7581

131a2h
3m
5079

141b2i
3n
4085

151b2j
3o
5582

161b2h3p
4589

171b2k
3q
4590

181b2l
3r
9084

191b2m
3s
9088

201a2n
3t
9086

211b2o
3u
9091

221a2p
3v
9079

231a2s
3w
9076

aReaction conditions: carbonyl compounds (1.0 mmol), 2-amino-5-chlorobenzophenone or 2-amino benzophenone (1 mmol), NbCl5 (0.1 mmol), and glycerol (2 mL); reactions conducted at 110°C.
bThe yield refers to pure isolated product.

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