Saccharomyces cerevisiae Catalyzed Cyclocondensation Reaction: Synthesis of Pyrazoline

Table 1

Effect of solvent on synthesis of pyrazoline catalyzed by baker’s yeast.

Entry	Solvent	Time (h)	Yield (%)
1	Ethanol	32	82
2	Methanol	32	86
3	Ethanol + water	32	70
4	Methanol + water	32	70
5	can	32	55
6	DCM	32	55
7	DMF	32	50
8	DMSO	32	57
9	THF	32	54

Reaction condition: chalcone (5 mmol), hydrazine hydrate (10 mmol), and baker’s yeast (2 g) in solvent (15 mL) under room temperature. Isolated yields.