Journal of Biomarkers / 2013 / Article / Tab 3

Research Article

Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes)

Table 3

ANOVA -statistics ( values) for 5 covariates in 6 datasets.

DatasetHCV infectionDecade of life1SexHealth statusCVD

Casewise deletion11.074 (0.001)**2.800 (0.096)0.013 (0.910)0.217 (0.642)1.385 (0.241)
QL33.230 (<0.000)**2.211 (0.112)0.078 (0.780)2.601 (0.108)0.881 (0.349)
QL/2
48.518 (<0.000)**1.733 (0.172)0.279 (0.598)6.630 (0.011)*0.327 (0.568)
Zero
50.860 (<0.000)**1.231 (0.294)0.702 (0.403)9.739 (0.002)**0.044 (0.834)
MLE37.777 (<0.000)**1.333 (0.266)0.062 (0.803)7.284 (0.007)**0.739 (0.391)
MI
47.208 (<0.000)**3.738 (0.045)*0.068 (0.794)4.083 (0.044)*0.513 (0.474)

-statistics ( value) for 5 covariates (HCV infection, age by decade of life, sex, health, and cardiovascular disease), for each of 6 different datasets used to handle missing data. Datasets include casewise deletion (the original left-censored data with 72 sub-threshold nondetects), 3 substitution datasets [QL, QL/2 or Zero], MLE (a single imputation based on maximum likelihood estimation from a log-normal distribution), and MI (multiple imputation of estimates based on the variance-covariance matrix plus random error).
, .
1A single degree of freedom linear contrast (−1 0 +1) was used to test the hypothesis that hsCRP increased linearly with decade of life (10–19 yr olds, 20–29 yr olds, and 30+ yr olds).

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