Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes)

Table 3

ANOVA 𝐹-statistics (𝑃 values) for 5 covariates in 6 datasets.

Dataset	HCV infection	Decade of life^1	Sex	Health status	CVD
Casewise deletion	11.074 (0.001)**	2.800 (0.096)	0.013 (0.910)	0.217 (0.642)	1.385 (0.241)
QL	33.230 (<0.000)**	2.211 (0.112)	0.078 (0.780)	2.601 (0.108)	0.881 (0.349)
QL/2	48.518 (<0.000)**	1.733 (0.172)	0.279 (0.598)	6.630 (0.011)*	0.327 (0.568)
Zero	50.860 (<0.000)**	1.231 (0.294)	0.702 (0.403)	9.739 (0.002)**	0.044 (0.834)
MLE	37.777 (<0.000)**	1.333 (0.266)	0.062 (0.803)	7.284 (0.007)**	0.739 (0.391)
MI	47.208 (<0.000)**	3.738 (0.045)*	0.068 (0.794)	4.083 (0.044)*	0.513 (0.474)

𝐹-statistics (𝑃 value) for 5 covariates (HCV infection, age by decade of life, sex, health, and cardiovascular disease), for each of 6 different datasets used to handle missing data. Datasets include casewise deletion (the original left-censored data with 72 sub-threshold nondetects), 3 substitution datasets [QL, QL/2 or Zero], MLE (a single imputation based on maximum likelihood estimation from a log-normal distribution), and MI (multiple imputation of estimates based on the variance-covariance matrix plus random error).
^∗𝑃<0.05, ^∗∗𝑃<0.01.
¹A single degree of freedom linear contrast (−1 0 +1) was used to test the hypothesis that hsCRP increased linearly with decade of life (10–19 yr olds, 20–29 yr olds, and 30+ yr olds).