Table of Contents
Journal of Biomarkers
Volume 2014, Article ID 106150, 9 pages
Research Article

Relationships between Plasma Micronutrients, Serum IgE, and Skin Test Reactivity and Asthma among School Children in Rural Southwest Nigeria

1Center for Clinical Cancer Genetics and the Center for Global Health, University of Chicago, Chicago, IL 60637, USA
2College of Medicine, University of Ibadan, PMB 5017, Ibadan, Oyo State, Nigeria
3Healthy Life for All Foundation, P.O. Box 3017, Ibadan, Oyo State, Nigeria
4Section of Pulmonary and Critical Care, Department of Medicine and the Center for Global Health, University of Chicago, 5841 South Maryland Avenue, MC 6076, Chicago, IL 60637, USA

Received 9 December 2013; Revised 18 April 2014; Accepted 5 May 2014; Published 26 May 2014

Academic Editor: Philip Thomas

Copyright © 2014 Oluwafemi Oluwole et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Increasing prevalence of asthma has been attributed to changes in lifestyle and environmental exposures. We conducted a case-control study to investigate the relationship between serum micronutrients and asthma in rural school children in Nigeria. Methods. We administered questionnaires to 1,562 children to identify children with asthma. Serum concentration levels of 12 micronutrients were determined in asthma cases () and controls (). Allergy skin prick test and spirometry were also performed. Results. Plasma levels of the following micronutrients were significantly different between cases and controls: calcium ( versus  mg/dL; ), manganese ( versus  mg/L; ), selenium ( versus μg/L; ), and albumin ( versus  g/dL; ). Plasma concentrations of iron and selenium were positively correlated with lung function, ( in each case) while manganese serum concentration was negatively correlated with asthma (; ). Conclusions. Children with asthma had reduced levels of plasma manganese, calcium, and albumin but raised level of selenium. The protective or risk effects of these micronutrients on asthma warrant further investigation.