A Panel of Cancer Testis Antigens and Clinical Risk Factors to Predict Metastasis in Colorectal Cancer

Table 3

Correlation between clinicopathologic risk factors and expression frequency of CTA.

Risk factors	PAGE4			SCP-1			SPANXA1
	−	+	𝑃 value	−	+	𝑃 value	−	+	𝑃 value
Gender
Male (𝑛=37)	59	41	0.818	76	24	0.617	16	84	1
Female (𝑛=40)	55	45		70	30		15	85
Age
>51 (𝑛=41)	54	46	0.645	71	29	0.799	80	20	0.645
<51 (𝑛=36)	61	39		75	25		89	11
Tumor location
Colon (32)	40	60	0.493	49	51	0.262	30	70	0.365
Rectum (45)	37	63		60	40		38	62
T category
T1 (𝑛=0)	0	0	0.057	0	0	0.143	0	0	0.482
T2 (𝑛=24)	75	25		79	21		83	17
T3 (𝑛=45)	53	47		76	24		82	18
T4 (𝑛=7)	29	71		43	57		100	0
M category
M0 (𝑛=41)	85	15	0.001*	85	15	0.011*	85	15	1
M1 (𝑛=36)	25	75		62	38		83	17
N category
N0 (𝑛=38)	76	24	0.002*	87	13	0.003*	92	8	0.181
N1 (𝑛=25)	28	72		48	52		76	24
N2 (𝑛=14)	57	43		79	21		79	21
Tumor size
<5 (𝑛=38)	53	47	0.355	74	26	0.798	80	20	0.623
≥5 (𝑛=36)	64	36		69	31		67	33

Data are percentages of patients with (+) or without (−) the gene expression.
*Statistically significant, 𝑃<0.05.