A Study on MTHFR C677T Gene Polymorphism and Alcohol Dependence among Meiteis of Manipur, India

Table 2

Genotypic and allelic frequency distribution of MTHFR C677T gene polymorphism among different patterns of alcohol consumption.

Genetic Marker (MTHFR C677T)	AD cases ()	Controls (ND + OD + MD) ()	ND ()	OD ()	MD ()	( value)
						CC (%)	91 (65.47)	228 (72.84)	89 (73.55)	81 (71.68)	58 (73.42)	0.283	0.366	0.876	0.352
CT (%)	44 (31.65)	78 (24.92)	29 (23.97)	28 (24.78)	21 (26.58)
TT (%)	4 (2.88)	7 (2.24)	3 (2.48)	4 (3.54)	0
C (frequency)	226 (0.81)	534 (0.85)	207 (0.86)	190 (0.84)	137 (0.87)	0.129	0.334	0.901	0.378
T (frequency)	52 (0.19)	92 (0.15)	38 (0.14)	36 (0.16)	21 (0.13)

: number; ND: nondrinkers; OD: occasional drinkers; MD: moderate drinkers.
: likelihood ratio test comparing genotype and allele frequency; = AD versus control (ND + OD + MD); = AD versus ND; = ND versus OD; = ND versus MD; significance level at 5%.