Journal of Biomarkers / 2014 / Article / Tab 2

Research Article

Functional Epigenetic Analysis of Prostate Carcinoma: A Role for Seryl-tRNA Synthetase?

Table 2

List of upregulated genes after bioinformatics analyses1.

Gene symbol2Gene nameLocationFold changeCpG island3Digital Northern4

ADRA2A adrenergic, alpha-2A-, receptor10q25.22.31YESD
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 604q32.32.97yesS
POTEFPOTE ankyrin domain family, member F2q21.12.15yesD
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 589p123.75yesS
IGF1RInsulin-like growth factor 1 receptor15q26.32.72yesS
INPP4BInositol polyphosphate-4-phosphatase, type II4q31.212.63yesD
IFI6Interferon, alpha-inducible protein 61p354.86yesD
TXNIP * Thioredoxin interacting protein1q21.14.65YESD
ADAM32ADAM metallopeptidase domain 328p11.223.73yesS
STC2Stanniocalcin 25q35.13.68YESS
BEST1Bestrophin 111q133.63YESS
ASNSAsparagine synthetase (glutamine-hydrolyzing)7q21.33.39YESD
CTHCystathionase (cystathionine gamma-lyase)1p31.13.36yesS
C12orf39Chromosome 12 open reading frame 3912p12.13.19YESS
JHDM1DJumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)7q343.08yesS
PPP1R15AProtein phosphatase 1, regulatory subunit 15A19q13.22.99YESS
SPRY4 * Sprouty homolog 4 (Drosophila)5q31.32.96YESS
ZC3H6Zinc finger CCCH-type containing 62q132.87yesS
TMEM156Transmembrane protein 1564p142.87yesS
FAM129AFamily with sequence similarity 129, member A1q252.80yesS
CDRT1CMT1A duplicated region transcript 117p122.74yesS
UPP1Uridine phosphorylase 17p12.32.71yesD
MAP2Microtubule-associated protein 22q34-q352.65yesS
MOCOSMolybdenum cofactor sulfurase18q122.59yesS
C6orf48Chromosome 6 open reading frame 486p21.32.58YESS
PYROXD1Pyridine nucleotide-disulphide oxidoreductase domain 112p12.12.54yesS
ZNF814Zinc finger protein 81419q13.432.52yesS
CLDN1Claudin 13q28-q292.52yesS
ABLIM3Actin binding LIM protein family, member 35q322.52yesD
DDIT4DNA-damage-inducible transcript 410q22.12.51YESS
TFPI2Tissue factor pathway inhibitor 27q222.51YESS
TUBE1Tubulin, epsilon 16q212.45yesD
GADD45A * Growth arrest and DNA-damage-inducible, alpha1p31.22.36YESS
FRZBFrizzled-related protein2qter2.34yesS
C5orf28Chromosome 5 open reading frame 285p122.33yesD
SERPINB8Serpin peptidase inhibitor, clade B (ovalbumin), member 818q22.12.33yesS
ZNF300Zinc finger protein 3005q33.12.32yesS
ZDHHC11Zinc finger, DHHC-type containing 115p15.332.29yesS
GTPBP2GTP binding protein 26p212.27YESD
MKXMohawk homeobox10p12.12.24yesS
CD274CD274 molecule9p242.22yesS
ZNF643Zinc finger protein 6431p34.22.19yesS
C9orf150Leucine rich adaptor protein 1-like9p232.19yesS
TESTestis derived transcript (3 LIM domains)7q31.22.17yesS
PSAT1Phosphoserine aminotransferase 19q21.22.16YESS
PAX6Paired box 611p132.15YESS
ETV5ETS variant 53q282.11yesS
SARSSeryl-tRNA synthetase1p13.32.10YESD
CD226CD226 molecule18q22.32.04yesS
GDPD1Glycerophosphodiester phosphodiesterase domain containing 117q222.01yesS
LETM2Leucine zipper-EF-hand containing transmembrane protein 28p11.2 32.01YESS

Selected 52 genes that showed at least 2-fold upregulation in two prostate cancer cell lines.
2Gene names in bold were analyzed by RT-qPCR. Gene name in italic with asterisk indicates gene previously identified and hypermethylated in PCa but not analyzed by us. Gene names in bold italic with asterisk indicate genes previously identified and hypermethylated in PCa and analyzed in this paper.
3Various writing styles indicate the size of CpG island(s): YES, the largest size; yes, the smallest size.
4S: equally expressed in normal and malignant tissue; D: increased expression in normal prostate tissue.

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