Table of Contents
Journal of Biomarkers
Volume 2015, Article ID 425310, 5 pages
Research Article

In Search of Biomarkers for Idiopathic Scoliosis: Leptin and BMP4 Functional Polymorphisms

1National Genetic Laboratory, Department of Obstetrics and Gynecology, Faculty of Medicine, Medical University, Sofia, 2 Zdrave Street, 14 Floor, 1431 Sofia, Bulgaria
2Tokuda Hospital Sofia, Orthopedic and Traumatology Clinic, 51B Nikola Vaptsarov Boulevard, 1407 Sofia, Bulgaria
3University Orthopedic Hospital “Professor Boycho Boychev”, Medical University, Sofia, 56 Nikola Petkov Boulevard, 1614 Sofia, Bulgaria
4Molecular Medicine Center, Medical University, Sofia, 2 Zdrave Street, 14 floor, 1431 Sofia, Bulgaria

Received 23 May 2015; Revised 10 July 2015; Accepted 12 July 2015

Academic Editor: Shozo Yano

Copyright © 2015 Svetla Nikolova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Idiopathic scoliosis (IS) is the most common spinal disorder in children and adolescents. The current consensus on IS maintains that it has a multifactorial etiology with genetic predisposition factors. In the present study the association of two functional polymorphisms of leptin (rs7799039) and BMP4 (rs4898820) with susceptibility to IS and curve severity was investigated in a Bulgarian population sample. The molecular detection of the genotypes was performed by amplification followed by restriction technology. The statistical analysis was performed by Pearson’s chi-squared test. This case-control study revealed no statistically significant association between the functional polymorphisms of leptin and BMP4 and susceptibility to IS or curve progression (). On the basis of these results the examined polymorphic variants of leptin and BMP4 could not be considered as genetic variants with predisposition effect or as risk factors for the progression of the curve. In addition, these results do not exclude a synergistic effect of the promoter polymorphisms of leptin and BMP4 in the etiology and pathogenesis of IS. The identification of molecular markers for IS could be useful for early detection and prognosis of the risk for a rapid progression of the curve. That would permit early stage treatment of the patient with the least invasive procedures.