Research Article
In Search of Biomarkers for Idiopathic Scoliosis: Leptin and BMP4 Functional Polymorphisms
Table 1
Genotype and allele frequency distributions in patients (
) with idiopathic scoliosis (IS) and healthy controls (
).
| Gene,
polymorphism | Genotype,
allele | Cases
, % | Controls
, % | value |
| Leptin
rs7799039 | AA | 25 (27.8) | 55 (30.6) |
0.64 | | AG | 42 (46.7) | 88 (48.9) | | GG | 23 (25.6) | 37 (20.6) | | A | 92 (51.1) | 198 (55.0) |
0.39 | | G | 88 (48.9) | 162 (45.0) |
| BMP4
rs4898820 | TT | 27 (30.0) | 46 (25.6) |
0.74 | | GT | 46 (51.1) | 99 (55.0) | | GG | 17 (18.9) | 35 (19.4) | | T | 100 (55.6) | 191 (53.1) |
0.58 | | G | 80 (44.4) | 169 (46.9) |
|
|
A -value < 0.05 was considered to be statistically significant. BMP4 indicates bone morphogenetic protein 4.
|
