Journal of Biomarkers / 2015 / Article / Tab 2

Research Article

In Search of Biomarkers for Idiopathic Scoliosis: Leptin and BMP4 Functional Polymorphisms

Table 2

Odds ratios of genotypes and alleles in different subgroups with idiopathic scoliosis (IS).

SubgroupGene,
polymorphism
Genotype, allele valueOR [95% CI]

General () Leptin
rs7799039
AA vs. GG
A vs. G
0.38
0.39
1.37 [0.68–2.76]
1.17 [0.82–1.67]
BMP4
rs4898820
TT vs. GG
T vs. G
0.62
0.58
1.21 [0.57–2.56]
1.11 [0.77–1.58]

AIS () Leptin
rs7799039
AA vs. GG
A vs. G
0.38
0.40
1.41 [0.65–3.03]
1.19 [0.80–1.77]
BMP4
rs4898820
TT vs. GG
T vs. G
0.24
0.23
1.67 [0.70–3.98]
1.28 [0.85–1.91]

Familial history of IS () Leptin
rs7799039
AA vs. GG
A vs. G
0.23
0.23
2.08 [0.61–7.06]
1.43 [0.79–2.60]
BMP4
rs4898820
TT vs. GG
T vs. G
0.19
0.15
3.42 [0.7–16.86]
1.57 [0.85–2.91]

Cobb angle >40° () Leptin
rs7799039
AA vs. GG
A vs. G
0.63
0.65
1.20 [0.56–2.58]
1.09 [0.74–1.61]
BMP4
rs4898820
TT vs. GG
T vs. G
1
1
1.01 [0.46–2.26]
1.02 [0.69–1.50]

Thoracic scoliosis () Leptin
rs7799039
AA vs. GG
A vs. G
0.86
1
1.07 [0.47–2.45]
1.02 [0.66–1.56]
BMP4
rs4898820
TT vs. GG
T vs. G
0.29
0.19
1.60 [0.67–3.82]
1.34 [0.86–2.07]

S-shaped scoliosis () Leptin
rs7799039
AA vs. GG
A vs. G
0.79
0.84
1.16 [0.40–3.38]
1.06 [0.60–1.86]
BMP4
rs4898820
TT vs. GG
T vs. G
0.92
0.92
1.07 [0.31–3.64]
1.02 [0.58–1.80]

Males () Leptin
rs7799039
AA vs. GG
A vs. G
1
0.82
1.16 [0.21–6.56]
1.07 [0.45–2.50]
BMP4
rs4898820
TT vs. GG
T vs. G
0.70
0.46
1.45 [0.28–7.64]
1.39 [0.58–3.37]

Females ()Leptin
rs7799039
AA vs. GG
A vs. G
0.30
0.31
1.50 [0.69–3.25]
1.23 [0.83–1.82]
BMP4
rs4898820
TT vs. GG
T vs. G
0.79
0.79
1.12 [0.48–2.63]
1.06 [0.71–1.57]

A value of was considered to be statistically significant. BMP4 indicates bone morphogenetic protein 4; AIS: adolescent idiopathic scoliosis; OR: odds ratio; CI: confidence interval.

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