Association Study between Promoter Polymorphism of TPH1 and Progression of Idiopathic Scoliosis
Table 1
Odds ratios of genotypes and alleles of tryptophan hydroxylase 1 (TPH1) polymorphism rs10488682 (T/A) in subgroups with different curve severity.
Subgroup
Genotype, allele
(case/control)
value
OR [95% CI]
Progressive IS Cobb angle > 40° (, )
TT versus AA
5/17 versus 43/135
1
1.10 0.37–3.22]
TT + TA versus AA
41/75 versus 43/135
0.07
1.61 0.97–2.69]
TT versus TA + AA
5/17 versus 79/193
0.82
0.89 0.31–2.54]
T versus A
46/92 versus 122/328
0.16
1.34 0.89–2.03]
Nonprogressive or slowly progressive IS Cobb angle < 40° (, )
TT versus AA
2/17 versus 11/135
0.62
1.71 0.34–8.53]
TT + TA versus AA
10/75 versus 11/135
0.48
1.54 0.62–3.79]
TT versus TA + AA
2/17 versus 19/193
0.64
1.47 0.31–6.98]
T versus A
12/92 versus 30/328
0.33
1.43 0.70–2.90]
A value of was considered to be statistically significant. OR indicates odds ratio; CI, confidence interval; , number of patients; , number of controls.
