Association Study between Promoter Polymorphism of TPH1 and Progression of Idiopathic Scoliosis

Table 2

Odds ratios of genotypes and alleles of tryptophan hydroxylase 1 (TPH1) polymorphism rs10488682 (T/A) in subgroups with different curve pattern.

Curve pattern	Genotype, allele	()	value	OR [95% CI]
Thoracic/(thoracolumbar + lumbar); (, )	TT versus AA	4/3 versus 32/22	1	0.92 0.19–4.51]
	TT + TA versus AA	30/21 versus 32/22	1	0.98 0.45–2.14]
	TT versus TA + AA	4/3 versus 58/40	1	0.92 0.20–4.33]
	T versus A	34/24 versus 90/62	1	0.98 0.53–1.80]
Thoracolumbar/(thoracic + lumbar); (, )	TT versus AA	1/6 versus 15/39	0.66	0.43 0.05–3.91]
	TT + TA versus AA	16/35 versus 15/39	1	0.98 0.45–2.14]
	TT versus TA + AA	1/6 versus 30/68	1	0.92 0.20–4.33]
	T versus A	17/41 versus 45/107	1	0.98 0.53–1.80]
Lumbar/(thoracolumbar + thoracic); (, )	TT versus AA	2/5 versus 7/47	0.58	2.69 0.43–16.7]
	TT + TA versus AA	5/46 versus 7/47	0.76	0.73 0.22–2.47]
	TT versus TA + AA	2/5 versus 10/88	0.18	3.52 0.60–20.6]
	T versus A	7/51 versus 17/135	1	1.09 0.43–2.78]

A value of was considered to be statistically significant. OR indicates odds ratio; CI, confidence interval; , , number of patients.