Table of Contents
Journal of Biomarkers
Volume 2017, Article ID 4737082, 5 pages
Research Article

The Circadian Rhythm of Copeptin, the C-Terminal Portion of Arginine Vasopressin

1Department of Endocrinology, Diabetes and Metabolism, University Hospital of Basel, 4031 Basel, Switzerland
2Department of Clinical Pharmacology, University Hospital of Basel, 4031 Basel, Switzerland

Correspondence should be addressed to Svetlana Beglinger; hc.bsu@regnilgeb.analtevs

Received 27 March 2017; Accepted 2 May 2017; Published 1 June 2017

Academic Editor: Kasper Karmark Iversen

Copyright © 2017 Svetlana Beglinger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Several studies have investigated copeptin as a prognostic marker of different acute diseases and as a diagnostic marker in disorders of water and salt homeostasis. However, no data of the normal circadian rhythm of copeptin in healthy subjects are available. Aim. To investigate the circadian rhythm of copeptin in healthy subjects under standardized conditions. Methods. 19 healthy volunteers aged 18 to 53 years, male and female, were studied in a prospective observational study. In all 19 participants, blood samples for copeptin were taken in regular intervals of 30 minutes for 24 hours after a fasting period of minimum 8 hours. Results. The mean values of copeptin showed a circadian rhythm, similar to that described for AVP release, with a trend towards higher levels ( pmol/L) at night and early morning between 4 am and 6 am and lowest levels ( pmol/L) in the late afternoon between 5 pm and 7 pm. This finding was only observed in individuals with initial higher copeptin levels, whereas in individuals with lower basal copeptin levels no circadian rhythm was observed. Conclusion. There is evidence for a circadian rhythm in copeptin release during 24 hours, however, of minor extent. These findings suggest that copeptin levels can be determined irrespectively of the time of the day.