Table of Contents
Journal of Biomarkers
Volume 2017 (2017), Article ID 7406959, 7 pages
Research Article

Cystatin-C as a Marker for Renal Impairment in Preeclampsia

1Department of Biochemistry, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
2Department of Biochemistry, School of Medicine, Xavier University, Oranjestad, Aruba
3Department of Obstetrics and Gynecology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
4Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal

Correspondence should be addressed to Apeksha Niraula

Received 22 March 2017; Revised 4 June 2017; Accepted 7 June 2017; Published 11 July 2017

Academic Editor: Kasper Karmark Iversen

Copyright © 2017 Apeksha Niraula et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Preeclampsia is a devastating pregnancy-associated disorder characterized by the onset of hypertension, proteinuria, and edema with limited plausible pathophysiology known. Cystatin-C, a novel marker for the detection of renal impairment, is increased in preeclampsia at an early stage. This study was aimed to evaluate the diagnostic efficiency of Cystatin-C as an early marker of renal function in preeclampsia comparing it to the traditional renal markers. A hospital based comparative cross-sectional study was performed on 104 women (52 diagnosed cases of preeclampsia and 52 healthy pregnant women). Concentrations of Cystatin-C, creatinine, urea, and uric acid were measured in both the study groups. Mean serum Cystatin-C and uric acid levels were elevated in preeclampsia cases compared to controls (1.15 ± 0.37 versus 0.55 ± 0.12; 5.40 ± 1.44 versus 3.97 ± 0.68, resp.). ROC curve depicted that Cystatin-C had the highest diagnostic efficiency (sensitivity, 88.24%; specificity, 98.04%) compared to creatinine and uric acid. Serum Cystatin-C consequently seemed to closely reflect the renal functional changes, which are believed to lead to increased blood pressure levels and urinary excretion of albumin and may thus function as a marker for the stage of the transition between normal adaptive renal changes at term and preeclampsia.