Cystatin-C as a Marker for Renal Impairment in Preeclampsia

Table 5

Showing sensitivity and specificity of various renal markers.

Parameters	AUC (95% CI)	Sensitivity	Specificity	+LR	−LR	PPV	NPV
Cystatin-C	0.993	88.24%	98.04%	45.0; (6.4–314.17)	0.12; (0.06–0.25)	97.83%	89.29%
Creatinine	0.423	62.75%	27.45%	0.86; (0.66–1.13)	1.36; (0.77–2.40)	46.38%	42.42%
Uric acid	0.815	79.07%	71.19%	3.78; (2.02–7.05)	0.40; (0.27–0.61)	66.67%	82.35%

There was a significant positive correlation between Cystatin-C level and uric acid (; value < 0.05). There was also a significant negative correlation between eGFR and serum Cystatin-C level (, ). The negative correlation implies that as the eGFR level decreases with the progression of kidney disease, there is a subsequent rise in serum Cystatin-C level.