Role of the Endothelium during Tumor Cell Metastasis: Is the Endothelium a Barrier or a Promoter for Cell Invasion and Metastasis?
Figure 3
Three currently discussed strategies for tumor cell transmigration through
an endothelial cell monolayer. (a) The tumor cell transmigrates through the
cytoplasm of the cell body. (b) The tumor cell induced apoptosis in the adjacent endothelial cell and
migrated through the hole in the endothelial cell layer. (c) The tumor cell
transmigrates through the endothelial cell-cell contacts without permanent
destroying the endothelial cell monolayer.
