Antidepressant Interactions with the NMDA NR1-1b Subunit

Figure 3

Intrinsic fluorescence quenching of the NR1-1b S1S2 domain with (a) TCAs and (b) SSRIs. To 5.29𝜇M NR1-1b S1S2 in buffer 3 was added quenchers in the following final concentrations: (a) TCAs-desipramine, trimipramine, or imipramine: 137𝜇M, maprotiline: 3.18 mM, nortriptyline: 2.08 mM; (b) SSRIs-paroxetine: 3.75 mM, sertraline: 1.88 mM, fluvoxamine: 2.81 mM.

(a)

(b)