Table of Contents
Journal of Biophysics
Volume 2010 (2010), Article ID 253763, 9 pages
http://dx.doi.org/10.1155/2010/253763
Research Article

Computational Laser Spectroscopy in a Biological Tissue

1Unité de Rayonnement Thermique, Département de Physique, Faculté des Sciences de Tunis, 2092 EL Manar I, Tunisia
2Unité de Biophysique, Faculté de Médecine de Sousse, Avenue Mohamed Karoui, 4002 Sousse, Tunisia

Received 3 July 2009; Revised 7 November 2009; Accepted 1 February 2010

Academic Editor: Yin Yeh

Copyright © 2010 M. Gantri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We present a numerical spectroscopic study of visible and infrared laser radiation in a biological tissue. We derive a solution of a general two-dimensional time dependent radiative transfer equation in a tissue-like medium. The used model is suitable for many situations especially when the external source is time-dependent or continuous. We use a control volume-discrete ordinate method associated with an implicit three-level second-order time differencing scheme. We consider a very thin rectangular biological-tissue-like medium submitted to a visible or a near infrared light sources. The RTE is solved for a set of different wavelength source. All sources are assumed to be monochromatic and collimated. The energetic fluence rate is computed at a set of detector points on the boundaries. According to the source type, we investigate either the steady-state or transient response of the medium. The used model is validated in the case of a heterogeneous tissue-like medium using referencing experimental results from the literature. Also, the developed model is used to study changes on transmitted light in a rat-liver tissue-like medium. Optical properties depend on the source wavelength and they are taken from the literature. In particular, light-transmission in the medium is studied for continuous wave and for short pulse.