Mechanisms of Cellular Uptake of Cell-Penetrating Peptides

Table 1

Some CPPs and their physical properties. ^aHydrophobicity calculated according to the values from von Heijne scale [10].

Peptide	No. of arginines	No. of lysines	Hydrophobicitya	No. of residues	Sequence	Total charge
R9 [11]	9	—	2.58	9	RRRRRRRRR	+9
TAT(48–60) [4]	6	2	2.37	13	GRKKRRQRRRPPQ	+8
Penetratin [7]	3	4	1.52	16	RQIKIWFQNRRMKWKK	+7
Pen-Arg [12]	7	—	1.49	16	RQIRIWFQNRRMRWRR	+7
pVEC [13]	4	2	1.10	18	LLIILRRRIRKQAHAHSK	+8
M918 [14]	7	—	0.93	22	MVTVLFRRLRIRRACGPPRVRV	+7
TP10 [15]	—	4	0.53	21	AGYLLGKINLKALAALAKKIL	+4