Informational Theory of Aging: The Life Extension Method Based on the Bone Marrow Transplantation

Table 1

Comparison of data on influence of bone marrow (BM) and mesenchymal stem cells transplantation on the mean lifespan of mice, obtained here and in experimental works of other authors.

Number	Date	Recipients	Donors	Number of mice	Irradiation	Source and amount of cells	Mean lifespan extension (Δ)
1	1991 [11]	Mutants gus/gus, young ♀	C57Bl/6, ♀	18 (e); 91 (c)	2–4 Gy	7 10^6, BM (total fraction)	Δ = 197%; (P = 0.005)
2	1991 [11]	C57Bl/6, young ♀	C57Bl/6, ♀	14 (e); 7 (c)	2–4 Gy	6 10^6, BM (total fraction)	Δ = −26%; (P = 0.2)
3	2005 [12]	C57Bl/6, old ♀; (16 months)	C57Bl/6 EGFP^+, young ♀	38 (e); 17 (c)	No irradiation	4 10^6, BM (total fraction) injections every 2 months	Δ = 6%; (P = 0.4)
4	2010 [13]	BALB, old ♀; (15 months)	BALB, fetal tissue, ♂	10 (e); 10 (c)	No irradiation	10 10^6, fetal tissue, mesenchymal stem cells,; 3 injections	Δ = 10%; (P = 0.1)
5	2011 [14]	BALB, old ♀; (18–24 months)	C57Bl/6 EGFP^+, young ♂	14 (e); 10 (c)	5 Gy	10^6, mesenchymal stem cells	Δ = 16%; (P = 0.05)
6	2011 [14]	BALB, old ♀; (18–24 months)	C57Bl/6 EGFP^+, old ♂; (20–24 months)	10 (e); 10 (c)	5 Gy	10^6, mesenchymal stem cells	Δ = 3%; (P = 0.6)
7	2012 [15]	C57Bl/6, old ♀; (21.5 months)	C57Bl/6, young ♂	8 (e); 9 (c)	No irradiation	25 10^6, BM (total fraction); 6 injections	Δ = 6%; (P = 0.4)
8	2013 [16]	mutants Wrn^−/−Tre^−/−, young ♂; (3 months)	C57Bl/6 EGFP^+, young ♀	13 (e); 8 (c)	10 Gy	5 10^6, BM; (total fraction)	Δ = 29%; (P = 0.01)
9	2014 our work [17]	C57Bl/6 EGFP, old ♀; (8 months)	C57Bl/6 EGFP^+, young ♀	11 (e); 12 (c)	No irradiation	2 10^6, BM; (total fraction) injection every 3 months	Δ = 34%; (P = 0.05)
10	This work	C57Bl/6 EGFP, old ♀; (8 months)	C57Bl/6 EGFP^+, young ♀	10 (e); 13 (c)	No irradiation	2 10^6, BM; (total fraction) injection every 3 months	Δ = 19%; (P = 0.20)
11	This work	C57Bl/6 EGFP, old ♀; (8 months)	C57Bl/6 EGFP^+, young ♀	21 (e); 25 (c)	No irradiation	2 10^6, BM; (total fraction) injection every 3 months	Δ = 25%; (P = 0.05)
12	This work	C57Bl/6 EGFP, old ♂; (8 months)	C57Bl/6 EGFP^+, young ♀, ♂	21 (e); 12 (c)	No irradiation	2 10^6, BM; (total fraction) injection every 3 months	Δ = 10%; (P = 0.40)
13	2014, our work [18]	BALB, old ♀; (13 months)	C57Bl/6 EGFP^+, young ♀, ♂	14 (e); 14 (c)	No irradiation	2 10^6, BM; (total fraction) injection every 3 months	Significant difference is not found

♀—female, ♂—male, e—experiment, c—control.