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Journal of Blood Transfusion
Volume 2015 (2015), Article ID 948304, 5 pages
Clinical Study

Low Dose Perioperative Intravenous Tranexamic Acid in Patients Undergoing Total Knee Arthroplasty: A Double-Blind Randomized Placebo Controlled Clinical Trial

1Orthopedic Department, Kashani Teaching Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2Students Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Received 19 May 2015; Revised 22 October 2015; Accepted 26 October 2015

Academic Editor: Pär Johansson

Copyright © 2015 Mahdi Motififard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Objectives. The null hypothesis of this study was that TA has no effect on postsurgical bleeding in patients undergoing TKA. Methods. This study was a double-blind randomized trial. In the first group (T) patients received 500 mg of intravenous Tranexamic acid (TA) twice (once preoperatively and once 3 hours postoperatively) and in the second group (P) they received slow infusion of normal saline as placebo. The primary outcome of the study was the level of Hb 48 hours after surgery. Results. Hb levels 48 hours after surgery as the primary outcome were and  (g/dL) in groups T and P, respectively, and the difference was statistically significant (). Statistically significant differences were also observed in Hb levels 6 and 24 hours after surgery, the drain output 48 hours after surgery, and the number of units of packed cells transfused between study groups (). There was no significant difference in duration of hospitalization between the study groups ( = n.s.). Conclusions. The low dose perioperative intravenous TA significantly reduces blood loss, requirement for blood transfusion, and drain output in patients undergoing TKA. However, duration of hospitalization did not change significantly.