LASSO-ing Potential Nuclear Receptor Agonists and Antagonists: A New Computational Method for Database Screening
(a) LASSO models implemented in ChemSpider. (b) LASSO scores for Mibolerone, a strong AR and ER binder found with a LASSO search on ChemSpider. The LASSO score is significant only for 4 targets: MR, AR, ER and PR while the rest of the 40 targets are all 0.10 or below for this molecule.
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