Natural Compound Isoliensinine Inhibits Stress-Induced Hair Greying by Blocking β2-Adrenoceptor

Figure 2

Isoliensinine could efficiently block NA/β2 signaling: (a) schematic diagram of NA-induced rise in intracellular Ca²⁺ concentration. (b) Propranolol and isoliensinine reduce the NA-induced P-PKA substrate levels rise (n ≥ 3 independent experiments are performed and representative data are shown). (c) Propranolol and isoliensinine abolish the NA-induced Ca2+ signal rise (n ≥ 3 independent experiments are performed and representative data are shown). (d) Statistical plot of calcium signal as a function of time.

(a)

(b)

(c)

(d)