Hydroxychloroquine: Pharmacokinetics and Toxicity

Table 4

HCQ concentrations in serum over time for COVID-19 patients with or without QTc prolongation.

Days		1	2	4	6	8	9	12
QTc [34]	n	20	20	20	20	20	20	20
	(HCQ)	0.13 ± 0.04	0.29 ± 0.19	0.22 ± 0.07	0.36 ± 0.25	0.59 ± 0.21	0.90 ± 0.19	0.29 ± 0.09
No QTc	n	56	297	127	64	41	20	40
	(HCQ)	0.10 ± 0.09	0.20 ± 0.13	0.38 ± 0.22	0.48 ± 0.30	0.57 ± 0.29	0.65 ± 0.30	0.52 ± 0.37

QTc: QTc prolongation; no QTc: no QTc prolongation. n: number of patients tested at each time point. (HCQ): HCQ concentrations over time (μg/mL, mean ± SD).