Table of Contents
Journal of Cancer Research
Volume 2013, Article ID 167576, 11 pages
Review Article

Derailing the UPS of Protein Turnover in Cancer and other Human Diseases

1Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857
2Sid Martin Biotechnology Incubator, University of Florida, 12085 Research Drive, Alachua, FL 32615, USA

Received 27 March 2013; Revised 1 July 2013; Accepted 15 July 2013

Academic Editor: Jianming Ying

Copyright © 2013 Jit Kong Cheong and Stephen I-Hong Hsu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Protein modifications by the covalent linkage of ubiquitin have significant involvement in many cellular processes, including stress response, oncogenesis, viral infection, transcription, protein turnover, organelle biogenesis, DNA repair, cellular differentiation, and cell cycle control. We provide a brief overview of the fundamentals of the regulation of protein turnover by the ubiquitin-proteasome pathway and discuss new therapeutic strategies that aim to mitigate the deleterious effects of its dysregulation in cancer and other human disease pathophysiology.