A Review of the Potential Utility of Mycophenolate Mofetil as a Cancer Therapeutic

Table 1

IMPDH gene overexpression in a number of malignancies.

Malignancy/cell lines	IMPDH	References
Osteosarcoma patients with poor response to chemotherapy	Elevated expression	Fellenberg et al., 2007 [13]
Osteosarcoma cells (SaO2 )	Exogenous overexpression induced chemoresistance	Fellenberg et al., 2010 [9]
MTX-resistant erythroleukemia cells (K562 )	Overexpressed	Peñuelas et al., 2005 [15]
MTX-resistant human colon cancer cells (HT29)	Overexpressed	Peñuelas et al., 2005 [14]
Leukemic cells (HL-60)	(i) Upregulated by induced proliferation; (ii) Downregulated by induced differentiation	Nagai et al., 1992 [16]

MTX: methotrexate.