Table of Contents
Journal of Crystallography
Volume 2013, Article ID 249672, 3 pages
Research Article

Crystal Structure of Apraclonidine Hydrochloride

Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan

Received 12 May 2013; Accepted 5 September 2013

Academic Editors: M. Akkurt, L. R. Gomes, E. D. Lowe, and P. M. Matias

Copyright © 2013 Noriaki Hirayama. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Apraclonidine is used for the treatment of postsurgical elevated intraocular pressure. The crystal structure of its hydrochloride, C9H10Cl2N4·HCl, was determined by X-ray analysis. The crystal belongs to space group with the cell dimensions , ,  Å, and °. The final (all reflections) value is 0.053. Apraclonidine has a more twisted structure than its related drug of clonidine. The nitrogen atom bridging the two rings is protonated.