Table of Contents
Journal of Crystallography
Volume 2013, Article ID 842803, 4 pages
Research Article

Structure of N-(3,4-Dimethoxyphenyl)pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4-amine, a New Inhibitor of CLK1 and DYRK1A Kinases

1Université Bordeaux Segalen, CNRS FRE 3396 - Pharmacochimie, F-33076 Bordeaux, France
2Université de Normandie, COBRA, UMR 6014 & FR 3038 and Université de Rouen, INSA Rouen, CNRS, IRCOF, 76821 Mont-Saint-Aignan Cedex, France
3ISM-CNRS UMR 5255, Université de Bordeaux, 33405 Talence Cedex, France

Received 9 September 2013; Accepted 21 November 2013

Academic Editors: M. Akkurt, L. R. Gomes, A. R. Ibrahim, and J. Jasinski

Copyright © 2013 Jean Guillon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The complete crystal structure of N-(3,4-dimethoxyphenyl)pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amine, synthesized via a Dimroth rearrangement and designed as new inhibitor of CLK1 and DYRK1A kinases, was established by a single-crystal X-ray diffraction. The crystal is orthorhombic, space group Pca21; , ,  Å, °,  Å3, and , C17H14N4O2S. Solid-state data could be used to enlighten the biological mechanism of action.