Journal of Drug Delivery / 2011 / Article / Tab 1

Review Article

An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines

Table 1

Examples of EMA- and/or FDA-approved vaccines based on micro- and nanoparticulated delivery systems. MF59 and AS03 are squalene- and tocopherol-based o/w emulsions, respectively. AS04 is composed of monophosphoril lipid A and alum. Virosomes are composed of viral-derived phospholipid bilayers, and virus-like particles (VLPs) are viral capsids lacking genetic material.

VaccineDelivery systemIndicationReference

RecombivaxAlumHepatitis B[17]
Engerix BAlumHepatitis B[18, 19]
Tripedia, Infanrix, DAPTACELAlumDiphteria, Tetanus and Pertussis[16]
FluadMF59Influenza/pandemic flu[20]
PandemrixAS03Pandemic flu[21]
FendrixAS04Hepatitis A[24]
EpaxalVirosomesHepatitis A[22]
InflexalVirosomesInfluenza[23]
CervarixAS04 + VLPsHuman papillomavirus[25, 26]
GardasilVLPs + AlumHuman papillomavirus[27]

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